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Our main research interest is in understanding how the nucleus of eukaryotic cells is spatially organized, and how the three-dimensional (3D) architecture of the genome influences gene expression regulation and genome integrity.

We are also interested in understanding the role of 3D genome architecture and genome fragility in the context of diseases such as cancer and neurodevelopmental disorders, and aim to harness our knowledge of genome organization and fragility to develop improved diagnostic approaches.

Towards these goals, we combine high-end microscopy methods, next-generation sequencing techniques, and advanced computational approaches, to assess chromosomal contacts, chromatin modifications, DNA breaks, chromosomal rearrangements and gene expression levels in cultured cells and patient-derived tissue samples.

180523_BiCroLabs